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Biochemical characterization of TyrA enzymes from Ignicoccus hospitalis and Haemophilus influenzae: a comparative study of the bifunctional and monofunctional dehydrogenase forms

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Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit