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18 Prevention Because of potential interactions from prolonged medication use, physicians should consider screening patients for vitamin B 12 deficiency if they have been taking proton pump inhibitors or H 2 blockers for more than 12 months, or metformin for more than four months

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Notably, treatment of LLC cells with 30 M DSF led to high ROS levels (Supplementary Figure S5B), in agreement with our previous findings that 30 M DSF significantly induced IFNB1 expression (Supplementary Figure S1A)

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