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Various drug combinations have been approved for the treatment of HCV genotype 1 infection, including both fixed co-formulations (sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, paritaprevir/ombitasvir with dasabuvir, grazoprevir/elbasvir) and combinations in which the doses of the two agents can be freely chosen (sofosbuvir plus simeprevir, sofosbuvir plus daclatasvir) (table 2) (10 17)