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The beneficial effects of Ru-hydroxide on hMSCs are manifested across multiple cellular processes, including cytoskeletal organization and focal adhesion (regulation of actin cytoskeleton and focal adhesion 70 ), DNA damage response mechanisms (p53 signaling pathway 71 ), cellular homeostasis (ECM-receptor interaction, cell senescence, and cell cycle regulation), and cell apoptosis (apoptosis) 71

(2022) 50:D2738