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With lower calcium levels in the cell, the predominant direction of myosin is toward dephosphorylation (mediated though myosin light chain phosphatase), which leads to smooth muscle relaxation

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Similarly, models with significant kidney or liver dysfunction are generally unsuitable, as impaired peptide clearance may heighten the risk of adverse effects

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Necroptosis participates in diverse pathological contexts, including metabolic-associated steatotic liver disease (MASLD) and cardiovascular diseases [7, 8]