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Poor responses to local therapies also suggest that pain may not be related to the bladder

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A randomized, open-label, parallel-group pilot trial enrolled 19 patients with major depressive disorder (MDD) who received either escitalopram (ESC, 10 mg/day) or ESC plus tetrahydrocurcumin (ESC + THC, 10 mg ESC + 200 mg THC per day) for 29 days

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In the cochlea, all three members of Dvls have been implicated to mediate the Wnt/PCP pathway (Figure 3)
