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A clinical trial (NCT02375880) evaluated the clinical value of DKN-01 in combination with gemcitabine and cisplatin in the treatment of patients with biliary tract cancer, followed by another clinical trial (NCT03645980) evaluating the antitumor activity and safety of DKN-01 in combination with sorafenib in patients with advanced HCC

doi: 10.1007/s13668-025-00671-y, 76

FangEFHouYPalikarasKAdriaanseBAKerrJSYangBet al

Pharmacological effects of HDACi in preclinical studies HDACi are powerful tools for the pharmacological intervention of HDACs and may show promise in the treatment of various human diseases including epilepsy in clinics

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Similarly, in spite of the fact that many GLP-1 drugs are approved by FDA, none of these companies had an FDA approval or, for example, a license to manufacture and distribute them from the drug companies that do