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Uncoupler FCCP (20 M) was added to FASN lox/lox -PyMT cells as a negative control

[14] confirmed the roles of NNMT in the development of T2D

Cooke, M

Free radicals, toxins, and oxidants can damage cellular structures, leaving cells without the ability to perform their functions adequately

302 Notably, microbial metabolites produced by commensal gut flora can limit pathogenic activities of microglia and astrocytes and suppress CNS inflammation in MS experimental models 303 and can contribute to the induction of specific LAMP1+TRAIL+ astrocytes that limit CNS inflammation by inducing T cell apoptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Pope LE, Dixon S