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They suggest inflammation/oxidative stress induced basal ganglia damage may be causing fatigue in both groups

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Drug Targets 21 , 785800 (2021)

In studying TNF-, an important inflammatory mediator in the pathogenesis of RA, it was found that small doses of TNF- could enhance Cys uptake and GSH synthesis by activating the NF-B pathway

High dose intravenous vitamin C and influenza: a case report