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Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology

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The CDR reframes chronic fatigue syndrome not as a failure of the body to respond, but as a state of incomplete healing

Clinical trials show retatrutide can reduce body weight by up to 24% after 48 weeks, significantly outperforming many current obesity treatments

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This includes engineering novel costimulatory domains (4-1BB/CD137, CD28, ICOS/CD278) and signaling components (e.g., CD40/MyD88, DAP10/12)