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Inhibition of TGR was shown in biochemical assays with recombinant protein, and in ex vivo worms by measurement of both TGR-generated fluorescent products from TRFS-Green and the decrease in the GSH/GSSG ratio

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Biomaterials 144 , 119129 (2017)

Ye Z, Xie T, Yan F, Wang L, Fang J, Wang Z, et al

In the ICH disease model, the role of GSH was first revealed by the team led by Dhandapani, who successively reported that GSH depletion leads to cell damage and death in hemin-induced astrocytes and endothelial cells (Laird et al., 2008

Enhanced transsulfuration activity driven by the glycine N -methyltransferase may contribute to cysteine biosynthesis and promote cancer cell survival in cysteine-limited microenvironment, which has been demonstrated to support tumor growth in vivo (50)