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Biochem Biophys Res Commun (2017) 491(2):41622
doi: 10.3390/antiox9100907, 36
The remarkable responses of relapsed/refractory patients to CAR-T cell therapy have led to broad testing of this strategy in clinical trials and increasing research within the field [1]
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Furthermore, ROS play a multitude of additional roles in initiating the T cell response, such as activating key transcription factors (e.g., NF-B, AP-1) and the mechanistic target of rapamycin complex 1 (mTORC1), the master regulator of cellular metabolism (79)
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