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All guide RNAs were validated in mouse embryos for their efficiency of generating indels on target genomic sequence, and two gRNAs targeting intron 1 and intron 2 were selected for preparing the microinjection mix

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In the proximal segment of the small bowel, the fluid transparency difference did not reach statistical significance (p = 0.1, Figure 1A)

Alterations at the rel locus in human lymphoma Oncogene 1991 6 : 12351241 Liptay S, Schmid RM, Perkins ND, Meltzer P, Altherr MR, McPherson JD, Wasmuth JJ, Nabel GJ