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Bianchi F, Sommariva M, Le Noci V, Camelliti S, Gagliano N, Giussani M, et al

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The history and gross necropsy findings may be distinctive, but histology to demonstrate specific cardiac and skeletal muscle lesions is necessary

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Later medications like semaglutide and tirzepatide are engineered versions - chemically modified human GLP-1 with structural changes that prevent degradation and extend half-life from seconds to days