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Notably, we delve into the critical challenges and considerations currently facing lymphatic nanomedicines, and futher propose effective strategies to address these issues

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As a result, aside from its protective role in -cells, butyrate has been proposed as a direct regulator of insulin secretion via GPR-mediated signaling

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This gradient mechanismranging from low-concentration signaling blockade to high-concentration multi-pathway synergyexhibits concentration-dependent anti-inflammatory activity in LPS-stimulated HaCaT keratinocytes (1.520 M), with no cytotoxicity observed below 6 M (Nguyen et al., 2022)