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This contact time allows sublingual absorption to occur
Reported plasma levels of phenformin after 50-100 mg of phenformin uptake in patients are ~1.7 M 67 , while tissue concentrations have not been assessed but are expected to be much higher as reported in animal models 68
doi: 10.1146/annurev.biochem.76.052705.162114
Cerebral alterations in a MPTP-mouse model of Parkinson's disease--an immunocytochemical study
Both are powerful IV therapies but serve different purposes
A results from two proteases cleaving APP: -secretase and -secretase
