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Although the mechanism that leads to the depletion of Th17 cells remains largely unknown, some of the proposed mechanisms include (i) a lack of HIV-inhibitory RNases in human Th17 cells leading to early, sustained depletion [59], (ii) decreased levels of IL-21-producing cells responsible for maintaining Th17 cells [60], and (iii) a depletion of CD103+ dendritic cells which promote Th17 differentiation [61]

Being a poor metabolizer may reduce the risk of cancers such as bladder or lung cancer

Neurosci Lett 649:156163 Reardon JT, Vaisman A, Chaney SG, Sancar A (1999) Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts

Someone with a less-responsive MC4R signal may achieve good initial weight loss on tirzepatide but hit a plateau sooner because the drug doesn't fully activate their compensatory energy-burning mechanisms

aeruginosa colonization leads to a cycle of continuous immune activation and tissue damage