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3 Role of immune cells in the pathogenesis of DKD 3.1 Macrophages Macrophages, which originate from circulating monocytes, are central innate immune cells that polarize into pro-inflammatory M1 or anti-inflammatory/pro-fibrotic M2 phenotypes in response to microenvironmental cues (50)

Hyperhomocysteinemia in chronic alcoholism: relations to folic acid and vitamins b6 and b12 status

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However, very high doses taken over long periods can potentially cause nerve issues or mask other nutrient deficiencies