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In mammalian cells, SMC3 undergoes acetylation by Establishment of Sister Chromatid Cohesion 1 (ESCO1), followed by acetylation by Establishment of Sister Chromatid Cohesion 2 (ESCO2)

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Vzhe-039, a novel structurally-enhanced allosteric hemoglobin effector inhibits sickling of SS erythrocytes in vitro, and exhibits improved pharmacologic properties in vivo

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