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Enasidenib: first global approval
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The activity of HK2 has been shown to play a key role in the progression of malignant tumors, with increased expression associated with poorer prognosis in GBM and various other cancers
TGF- could also be activated by the mediator protein complex subunit 12 (MED12), which may upregulate the mesenchymal marker expression and induce chemotherapy resistance in CRC (Brunen et al., 2013)
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