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Global trends in the incidence, prevalence, and years lived with disability of Parkinson's disease in 204 countries/territories from 1990 to 2019

Keywords: autoantibodies, cerebellar ataxia, encephalitis, GAD autoimmunity, hyperexcitability, stiff person syndrome Introduction GAD (glutamic acid decarboxylase) is a pyridoxal 5-phosphate-dependent enzyme, widely expressed within the central nervous system and pancreatic -cells, that catalyzes the conversion of the excitatory neurotransmitter l-glutamate to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)