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Keratinocyte migration, which is an integral part of re-epithelization is inhibited in high glucose conditions ( Figure 6A )

These agents also disrupt axonal continuity and show heightened neurotoxicity in children and in patients with predisposing risk factors [26]

Although this work focused on the contraceptive drug LNG, we anticipate that our design approach will be applicable to other hydrophobic drugs as well, which is important because the majority of new drugs developed in the pharmaceutical industry are poorly soluble in physiological fluids 38

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Molecular and Clinical Oncology