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With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis
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As an additional example to that of the trefoil peptides noted above, the peptide EGF (epidermal growth factor) is produced in human milk to promote growth of the gastrointestinal tract in newborn infants, but the same peptide aggressively stimulates the growth of breast cancer cells in adults
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Notably, islet incubation with FGF-21 was able to restore insulin secretion after in vitro Taz-KD
