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401,402 miR-21 in Schwann cell-derived EVs has beneficial effects on neurite outgrowth in vitro

Also, the glutathione molecule is too large to pass through cellular membranes, so even if you could get the glutathione molecules to the cells, you couldn't get it inside the cells

T.LangW.et al (2000)

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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

15: 950 Leeder JS
