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coagulans utilizes sporulation to remain dormant and resistant to gastric acidity until reaching the intestine

About 90% of the latter mutations occur in 6 ribosomal protein genes viz., RPS19, RPL5, RPS26, RPL11, RPL35A , and RPS24

& Cheng, Y

(2010) 298:H156570

The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism
