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doi: 10.1016/j.yexcr.2017.05.019 221 LaughnerETaghaviPChilesKMahonPCSemenzaGL

doi: 10.1007/s10637-011-9766-6 210 VoglDTMartinTGVijRHariPMikhaelJRSiegelDet al

109113,259,292,336343 In addition, prolonged hypoxia causes renal endothelium to produce pro-inflammatory adhesion molecules, cytokines, and chemokines that activate macrophages already resident within the kidney and also recruit additional inflammatory cells from the circulation

Numerous proteins involved in carbohydrate, protein, coenzyme, and nucleic acid metabolism were regulated with age, while regulators of protein quality control such as puromycin-sensitive aminopeptidase and heat shock proteins were altered with cognitive decline

Knockout of prolyl hydroxylase domain-containing protein 2 (PHD2) stabilized HIF-1 protein and activated HIF-1 signaling, which transcriptionally upregulated glutaminase 1 ( GLS1 ) expression leading to a decrease in ROS production and increases in cellular GSH levels, GSH/GSSG, and cell survival in murine periosteal progenitor cells, suggesting that HIF-1 signaling promotes glutaminolysis to provide glutamate for GSH synthesis (96)

Moreover, the Antioxidant activity of garlic can help with fertility by lowering the peroxidation of lipids (102)