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Meanwhile, SystemsAge markers capture aging in 11 distinct physiological systems: blood, brain, heart, hormone, immune, inflammatory, kidney, liver, lung, metabolic, and musculoskeletal [15]

Genetic studies do not show a single ME/CFS gene but instead highlight multiple pathways that increase susceptibility

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Thus, further studies are mandatory to better understand the mechanisms by which the combination of folic acid and -tocopherol acts to prevent neurodegeneration for the rational design of new therapeutic approaches