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Glutamine, but not leucine, was found to activate mTORC1 by a pathway requiring the ADP ribosylation factor-1 GTPase and vacuolar adenosine triphosphatase for mTORC1 translocation and fixation, respectively, to the lysosomal membrane

Radiother Oncol 128(3):442-451, 2018

TGF- Tumor Suppression through a Lethal EMT

And eudesmin could up-regulate the expression of the GABA A receptor and GAD65 (the key synthesis enzyme for GABAergic transmitters), as well as reduce the level of apoptotic caspase-3 [55]

In the met state, the copper ion at the active site chelates with a hydroxide ion (Fig