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including imbalances in key neurotransmitters, gamma aminobutyric acid (GABA) and glutamate [2], or alterations in cellular metabolism including mitochondrial function [3] and one-carbon signaling [4]

This study demonstrated that T FH cells and IL-21 are overproduced in T1D, challenging the established T H 1 paradigm

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The treatment with folic acid should be combined with pyridoxine in vitamin B 6 -deficient patients who are responders to an oral methionine load

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