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Physiol Rev 59:527605 Ng CF, Schafer FQ, Buettner GR, Rodgers VG (2007) The rate of cellular hydrogen peroxide removal shows dependency on GSH: mathematical insight into in vivo H2O2 and GPx concentrations

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Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death