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Most clinical data shows that GI symptoms peak around week two to three after a dose increase and gradually resolve within one to four weeks as your body's receptors become less sensitive to the constant signal
doi: 10.1101/2023.04.24.23288821 311 FaghyMADaltonCDuncanRArenaRAshtonREM

doi:10.1016/S0009-2797(03)00091-7 [DOI] [PubMed] [Google Scholar] 107.Mannelli P, Patkar A, Rozen S, Matson W, Krishnan R, Kaddurah-Daouk R

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Saudi Med J 37(4):369 Alharbi Y, Kapur A, Felder M, Barroilhet L, Pattnaik BR, Patankar MS (2020) Oxidative stress induced by the anti-cancer agents, plumbagin, and atovaquone, inhibits ion transport through Na+/K+-ATPase
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