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Some of the most common early warning signs include: Extreme Fatigue Feeling excessively tired even after a full nights rest Joint Pain and Swelling Increased stiffness and discomfort in the joints Skin Rashes Redness, irritation, or a butterfly-shaped rash across the cheeks and nose Low-Grade Fever A persistent mild fever without an obvious cause Brain Fog Difficulty concentrating, memory issues, and mental fatigue Chest Pain Discomfort caused by lung or heart inflammation Hair Loss Unexplained thinning or increased shedding of hair Many lupus patients report subtle symptoms before a full-blown flare occurs

Pancreatic enzymes and receptors in the distal ileum must be present along with the blood protein transcobalamin II to process B12

Neurologic complications can develop