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To assess the interaction between human Met and the macrocycles, human Met ectodomain-Fc chimera was immobilized to a surface density of 1,2001,600 response units (RUs) on a CM5 sensor chip using a human antibody capture kit (GE Healthcare)

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Remarkably, therapy by topical replacement of TGM1 corrected skin architecture and dramatically reduced transepidermal water loss (Aufenvenne et al., 2013)

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