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Proc Nat Acad Sci U S A (2002) 99(23):1480712.10.1073/pnas.192585799 65 BuffoniFIgnestiG

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The change induces difficulty in repairing ruptures of double-stranded DNA, increases ROS production, mitochondrial dysfunction, with concomitant oxidative stress and consequent cell apoptosis [10, 11]

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Enhanced histone H3 acetylation of the PD-L1 promoter via the COP1/c-Jun/HDAC3 axis is required for PD-L1 expression in drug-resistant cancer cells

Mauvais-Jarvis F, Kulkarni RN, Kahn CR