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VRK2 expression stratifies the response of PC to GSH-targeted treatment To further investigate the differential sensitivity to GSH inhibitors between VRK2-expressing and VRK2-deficient pancreatic tumors in vivo, we developed orthotopic pancreatic cancer models using Pan02 cells (Fig

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The co-substrate site (here termed site II) is seen in crystal structures in this work occupied by (a) the non-processable KG-analogue NOG (where atom C3 is substituted by nitrogen compared to KG) or (b) the co-product SA

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