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Retinoids work by binding to retinoic acid receptors in the nucleus, directly altering gene transcription

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Chamayou AC, Neelakantan MA, Thalamuthu S, Janiak C: The first vitamin B 6 zinc complex, pyridoxinato-zinc acetate: a 1D coordination polymer with polar packing through strong inter-chain hydrogen bonding

[] Another RCT administered 3 g/day of curcumin or a placebo to patients undergoing external beam radiotherapy (ClinicalTrials.gov Identifier: NCT01917890)

It is being studied, but it does not currently have the same FDA-approved prescribing status as semaglutide or tirzepatide for weight loss

This is especially true when dealing with natural extracts instead of pure compounds because even a minor component in the extract may affect the system via an unidentified pathway(s) and imitate Nrf2 involvement