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Research has demonstrated that augmented glutamine metabolism in CAFs gives rise to collagen-rich extracellular matrix and fosters tumor development [134, 135]

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Intrathecal clonidine and baclofen in the management of spasticity and neuropathic pain following spinal cord injury: a case study

In HT-29 xenograft-bearing nude mice, Gal-DOXs tumor-targeted accumulation was visualized by enhanced fluorescence up to 48 h, while free DOX cleared from the tumor site within 24 h