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Dual-action nanocarriers: liposomal or polymeric nanoparticles co-encapsulating IL-1 inhibitors and XOIs (e.g., febuxostat) achieve sequential neutralization of inflammatory cytokines and sustained XO inhibition, preventing crystal formation ( Gout and hyperuricemia management requires integrated approaches addressing metabolic dysregulation and organ-specific damage

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However, much of the research on NAC has revealed that its benefits are largely due to its role as a precursor to glutathione

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Moreover, SLC39A14 knockdown has been shown to significantly reduce Mn levels in multiple cell models, including A549 cells, HepG2 cells, human SH-SY5Y neuroblastoma cells, and brain microvascular endothelial cells (BMVECs) 67,68,69,70

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