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We monitored the response of NAPstar3, NAPstarC, and PeredoxDS probes expressed in wild-type cells, in cells deleted for the GLR1 gene (encoding glutathione reductase), and in cells deleted for TRX1 and TRX2 (encoding the two cytosolic thioredoxins)

Oxidized glutathione (GSSG), produced upon reduction of hydroperoxide by GPX, is recycled to its reduced state by GR and NADPH

doi: 10.1016/j.cell.2017.05.028

Guido J

K.O'BrienK

Aerobic training can improve fatty acid oxidation, enhance muscle metabolism, regulate insulin sensitivity, and improve amino acid and iron homeostasis, thereby mitigating the adverse effects of ferroptosis