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Even mild exertion causes a massive leakage of reactive oxygen species, overwhelming the body's depleted antioxidant defenses

[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Porto B.N., Alves L.S., Fernandez P.L., Dutra T.P., Figueiredo R.T., Graca-Souza A.V., Bozza M.T

Figure 2 shows the broader categories of treatment options for PD, while Figures 3, 4 show various existing treatment strategies for PD

ROS reactive nitrogen species

160 Studies have revealed that piperlongumine hydrolyzes to hydroxypiperlongumine within cellular environments, which then binds to GSTP1 as a GSH conjugate

GSH protects cells from oxidative stress-induced apoptosis by scavenging H 2 O 2 , and exogenous GSH supplementation enhances cell viability under oxidative conditions 34