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Increased climbing fiber lateral crossings on purkinje cell dendrites in the cerebellar hemisphere in essential tremor

Changes in TJ proteins, whether through degradation, dephosphorylation, or displacement, lead to a compromised barrier controlling the passage of toxins, undigested food particles and microorganisms through the epithelium and to elicit an immune response

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they can gain access to the brain by diapedesis once a recruitment signal (e.g., release of chemokines) has been produced

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