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Another study by Doherty et al [22] was done also on the finding that SLE patients PBL show mitochondrial dysfunction and oxidative stress

Through establishing an interleukin (IL)-1-stimulated chondrocytes, it was found that L-theanine could inhibit the nuclear factor kappa B (NF-B) pathway, thereby reducing the expression of proinflammatory factors, including cyclooxygenase-2 (COX-2), prostaglandin E2, inducible nitric oxide synthase, as well as NO, and protect the degradation of extracellular matrix (29)

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10.3390/antiox8020051 29 CericolaF.PortisE.ToppinoL.BarchiL.AcciarriN.CiriaciT.et al (2013)

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