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In contrast, the lifespan of mitochondrial electron transport chain deficient isp-1 mutant and raga-1 mutants, in which mTOR complex 1 activity is inhibited, remains unaffected by changes in the media (Figure 4C and D), indicating that the lifespan extension effects induced by mitochondria deficiency and TOR inhibition are resilient to environmental factors that interfere with metformin action in aging

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By effectively blunting the toxic accumulation of lactic acid and reducing systemic markers of muscle damage, L-carnitine demonstrated a clear, undeniable ability to improve energy metabolism and delay the onset of physical fatigue

This collaboration significantly enhanced the experience for the visiting students

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