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while the C max of imperatorin and isoimperatorin decreased, however, the retention time is prolonged and the absorption is delayed)
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Moreover, interest in combining systemic immunotherapy with local treatments targeting liver metastases to improve clinical outcomes and overcome drug resistance is increasing
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This indicates that downregulation of Adrb3 expression is an important consequence of both homologous and heterologous 3 -AR desensitization (Valentine et al., 2022)
