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94 There is one report of symptomatic individuals with null variants causing profound biotinidase deficiency who appear more likely to have hearing loss than symptomatic individuals with other profound deficiency variants

We suggest that only by deciphering the contribution of eosinophils to the complex, multi-faceted, systems that regulate homeostasis will we truly understand the etiology of the complex diseases and disorders with which eosinophils are historically associated and develop novel treatments that are targeted and efficient

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& Zinkernagel, A