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While the first studies showing this were in mice [14], human studies have corroborated these findings [200], although its importance in relationship to traditional clearance pathways across the BBB and subarachnoidal granulations has been challenging to quantify

However, RCC patients have a higher incidence of high-grade proteinuria, up to 78% [65, 78]

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doi: 10.1136/ard.2011.153312 36 WangJYChenXJZhangLPanYYGuZXHeSMet al

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