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Neurological: Numbness or tingling in the extremities (paresthesias), difficulty walking, balance problems, muscle weakness, vision problems, cognitive disorders (difficulty concentrating, memory loss), mood changes (depression, irritability)

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The incidence of LM in NSCLC patients ranges from 3.4 to 9.4%, with a higher frequency observed in subgroups with EGFR mutations and ALK rearrangements [127, 128]

Roychaudhuri R, Yang M, Deshpande A, Cole GM, Frautschy S, Lomakin A, Benedek GB, Teplow DB

192,193,194,195 Conversely, SIRT1 activity is reduced in high-energy states, which lower cellular NAD levels, such as during high-fat diet consumption or acute inflammatory responses