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But when they tried to administer it directly, they hit a fundamental problem: -MSH degrades within minutes in the bloodstream, making it impractical as a therapeutic agent

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3 Vascular malformations, lipomatosis, verrucal keratoses, and acrochordons can occur

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Although recurrent and metastatic tumors disappeared or diminished in size by radiation, tumors increased in size thereafter, despite additional adjuvant chemotherapy
