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MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions

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and contributes to the reduction of tiredness and fatigue

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An increased delivery of fatty acids to skeletal muscle, as well as diminished mitochondrial oxidation, results in increased intracellular content of fatty acid metabolites such as diacylglycerol (DAG), fatty acyl-CoAs, and ceramides