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H2AX: a sensitive molecular marker of DNA damage and repair

doi: 10.5604/17322693.1088339 99 BakerRNarlaRBakerJFWyshamKD

In the absence of intracel-lular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) reacts with nucleophilic groups of cellular proteins, resulting in hepatotoxicity.The chemical and toxicologic characterization of the electro-philic nature of the reactive acetaminophen metabolite has led to the development of effective antidotescysteamine and N -acetylcysteine

neoformans , part of the SCF(Fbp1) E3 ligase, triggers strong Th1-mediated immunity (Masso-Silva et al., 2018)

A collective statistical analysis including the results of published studies indicates the effectiveness of steroid therapy leading to the improvement of vision in more than 80% of eyes